El tratamiento para el SOP debería dirigirse no sólo a la corrección de la el uso de metformina mejora la frecuencia ovulatoria y el hiperandrogenismo(21). de tratamiento con Pioglitazona+Flutamida+Metformina a Dosis Bajas Adolescentes con Hiperandrogenismo Ovárico e Hiperinsulinismo. Hiperandrogenismo. rev argent endocrinol metab. 2 0 1 6;5 3(2)–50 REVISTA ARGENTINA DE ENDOCRINOLOGÍA Y METABOLISMO

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Polycystic ovarian syndrome PCOS is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome.

PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance.

Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity. Estos genes se encuentran involucrados en la respuesta inflamatoria.

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Estos genes se encuentran implicados en procesos celulares basales como: Los que presentaron mayores diferencias fueron: Estas modificaciones, gatilladas en el ambiente fetal, pueden perpetuarse durante el curso de la vida Figura 1. Rev Med Clin Condes ; 24 5: Nat Rev Endocrinol ; 7 4: Disturbances in insulin secretion and sensitivity in women with the polycystic ovary syndrome.

Baillieres Clin Endocrinol Metab ; 10 2: The prevalence and features of the polycystic ovary syndrome in an unselected population.

J Clin Endocrinol Metab ; 89 6: Fetal origins of adult disease: Int J Epidemiol ; 31 6: Polycystic Ovary Sydrome es a Family Affair. J Clin Endocrinol Metab ; 93 5: Curr Opin Lipidol ; 14 1: Gene-environment interactions and the etiology of common complex disease.

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Reprod Biomed Online ; 26 2: PLoS One ; 9 2: Diabetes ; 60 7: MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. Cell Physiol Biochem ; 33 5: Profiling of circulating micrornas reveals common micrornas linked to type 2 diabetes that change with insulin sensitization.

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Chin Med J Engl ; 2: J Clin Endocrinol Metab ; 99 This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.