Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

Author: Mihn Makinos
Country: Namibia
Language: English (Spanish)
Genre: Health and Food
Published (Last): 15 March 2007
Pages: 172
PDF File Size: 4.12 Mb
ePub File Size: 10.13 Mb
ISBN: 908-3-90407-656-2
Downloads: 42100
Price: Free* [*Free Regsitration Required]
Uploader: Duran

December Learn how and when to remove this template message. Thus, COMT inhibitors are clinically significant and beneficial adjunct to levodopa therapy in Parkinson’s al patients with end-of-dose fluctuations. Neurotransmitters and their receptors”.

ES2282924T3 – Inhibidores de la comt. – Google Patents

Oroszi G, Goldman D December Comparable effects on similar cognitive inhibidroes, the frontal lobes, and the neurotransmitter dopamine have also all been linked to schizophrenia. Given the preferential role of COMT in prefrontal dopamine degradation, the ValMet polymorphism is thought to exert its effects on cognition by modulating dopamine signaling in the frontal lobes.

The dyskinesias are managed by decreasing the daily levodopa dose in Parkinson’s disease patients with end-of-dose fluctuations. Entacapone acts mainly peripherally whereas tolcapone acts both peripherally and centrally. Catechol-O-methyl transferase Monoamine oxidase A B.


Catechol- O inhibidoores is involved in the inactivation of the catecholamine neurotransmitters dopamineepinephrineand norepinephrine. Student consult inhibiddores ed. COMT is the name given to the gene that codes for this enzyme. Cholinesterase AcetylcholinesteraseButyrylcholinesterase. EC number Enzyme superfamily Enzyme family List of enzymes. Both entacapone and tolcapone are well-tolerated. However, there seems to be a trend for tolcapone to induce more often diarrhoea and increase in liver transaminases compared with entacapone.

Principles of pharmacology 3rd ed.

The O in the name stands for oxygennot for ortho. Comf pharmacokinetically and clinically the mg dose of entacapone is the most effective dose compared with placebo. Journal of Oral Rehabilitation.

Catechol-O-methyltransferase – Wikipedia

Genetic variation with functional impact on cortical dopamine tone has a strong influence on reward experience in the flow of daily life. Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase.

Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. The British Journal of Psychiatry. Views Read Edit View history.

The Central Nervous System. Genes on human chromosome 22 EC 2. Temporomandibular joint dysfunction TMD does not appear to be a classic genetic disorder, however variations in the gene that codes for COMT have been suggested to be responsible for inheritance of a predisposition to develop TMD during life.

The best-studied is ValMet. Two of the nitrocatechols, entacapone Goetz CG May This “triple therapy” is becoming a standard in the treatment of Parkinson’s disease. This article relies too much on references to primary sources. Levodopaa precursor of catecholamines, is an important substrate of COMT.


Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase.

COMT inhibitors include tolcaponeentacapone and opicaponewhich are used in the treatment of Parkinson’s disease. The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine SAM. The gene variant has been shown to affect cognitive tasks broadly related to executive functionsuch as set shifting, response inhibition, abstract thought, and the acquisition of rules or task structure. It is increasingly recognised that allelic variation at the COMT gene are also relevant for emotional processing, as they seem to influence the interaction between prefrontal and limbic regions.

Tyrosine hydroxylase Aromatic L-amino acid decarboxylase Dopamine beta-hydroxylase Phenylethanolamine N-methyltransferase. This page was last edited on 21 Novemberat Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase. Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase.