Isosterism and Bioisosterism – Download as PDF File .pdf), Text File .txt) or read online. Pharmacology. Download Citation on ResearchGate | Isosterism and bioisosterism in drug design | In every scientific undertaking that is to break new ground, one has to have a. Aug 1, Isosterism and bioisosterism in drug design. By Alfred Burger. University of Virginia, Department of Chemistry,. Charlottesville, Virgina

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Hence alkylsulphonamido derivative of phenylepherine was found to retain activity. By modifying certain substituents, the pharmacological activity of the chalcone and its toxicity are also modified. Bivalent atom or groups.


Drug act as a Antihistamine. Alferrd Burger Bioisosteric Replacement. Classical bioisosterism was originally formulated by James Moir and refined by Irving Langmuir [2] as a response to the observation that different atoms with the same valence electron structure had similar biological properties. Go to Application Have a question?

Promising Starting Points for Drug Design”. Isosreric replacement involving cylic vs noncylic analog: Tetrazole anaion is 10 times more lipophilic than a carboxylic acid and drug absorption is enhanced bioisowterism a result 23 Carboxylic acid 5-Substiuted tetrazole H- acidic proton.

Bioisostere to increase absorption: Retrieved from ” https: Catechol- 16 PowerPoint Presentation: Bioisosteres for polar group: This page was last edited on 31 Octoberat Whereas classical bioisosteres commonly conserve much bioispsterism the same structural properties, nonclassical bioisosteres are much more dependent on the specific binding needs of the ligand in question and may substitute a linear islsterism group for a cyclic moiety, an alkyl group for a complex heteroatom moiety, or other changes that go biosiosterism beyond a simple atom-for-atom switch.


In medicinal chemistrybioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties to another chemical compound.

Another example is aromatic rings, a phenyl -C 6 H 5 ring can often be replaced by bioisosterrism different aromatic ring such as thiophene or naphthalene which may improve efficacy, change specificity of binding, or reduce metabolically labile sites on the molecule, resulting in better pharmacokinetic properties. Pharmacokinetics lipophilicity, hydrophilicity, p K aH-bonding are important Another example are chalcones bioisosteres. Burger define Bioisosteres as substituent’s or groups that have similar chemical and physical properties and which produce broadly similar biological propert i es.


All lily of the valley flower 13 Why Bioisosterism? For example, the replacement of a hydrogen atom with a fluorine atom at a site of metabolic oxidation in a drug candidate may prevent such metabolism from taking place.

WordPress Embed Customize Embed. It involves the study of effects of biologically active compounds on the basis of molecular structures or its physico-chemical properties.

Hydroxy group- -OH d. Why Lead Modification is Necessary?: Univalent atoms and groups.

Method of Lead discovery. Conclusion References 2 PowerPoint Presentation: Bioisosterism is used to reduce toxicity, change bioavailabilityor modify the activity of the lead compound, and may alter the metabolism of the lead.


The OH group is isosterisn by other group having ability to undergo H-bonding. Because the fluorine atom is similar in size to the hydrogen atom the overall topology of the molecule is not significantly affected, leaving the desired biological activity unaffected. By using this site, you agree to the Terms of Use and Privacy Policy.

Silafluofen is an organosilicon analogue of pyrethroid insecticidewherein a carbon center has been replaced by isosteric silicon.

Retrieved 15 Jan The lead is prototype compound that has the desired biological or pharmacological activity but may have many undesirable characterisics,like high toxicity, other biological activity, insolubility or metabolism problems. It has been proposed that key force field features, that is the pharmacophorebe patented instead. However, with a blocked pathway for metabolism, the drug candidate may have a longer half-life.

For fine tune of biological activity in order to- -Minimize toxicity -Modify the activity -Alter metabolism -Maximize bioavailability 7 PowerPoint Presentation: For fine tune of biological activity in order to- -Minimize toxicity -Modify the activity -Alter metabolism -Maximize bioavailability 7.